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Just turned 51, my dr, had me take DIM (days 1-10) and topical progesterone (days 20-27) when my period was regular, now its out of whack- haven't had it in . DIM may be effective at inhibiting aromatase. We do not recommend taking DIM capsules along with alcohol. DIM and other plant indoles are found in . The how long to take dim for estrogen dominance is a question that many people have. In the pilot study I mentioned first, urine analysis showed that DIM regulated estrogen metabolism in patients. Read Guide to using progesterone for women's health. Zeligs MA, Brownstone PK, Sharp ME, et al. I feel like it was removing my estrogen to the point it was putting me into menopause. And they're linked to high estrogen (and low progesterone). The most favorable of the three is 2OHE1. Taking DIM in high amounts can cause adverse side effects such as vomiting, headaches and nausea. Can I open the DIM capsule? #2. I am now Post-Menopausal (58) and am now, after higher doses, also, Hi I have estrogen D in the process of getting better im using cream at high dose my vit d levels are great. Women who are pregnant or nursing should avoid using DIM supplements. Fibroids, polyps, and endometrial lesions, like those seen in endometriosis, can also be stimulated by estrogen. What are some alternatives to diming out? "It takes . This increased burden can lead to problems such as diabetes and high blood pressure, both of which may also influence your period cycle. DIM may be helpful for breast health because it supports Phase 1 metabolism of estrogen in the liver, favoring 2OHE1. I really appreciate it! DIM can be taken on its own or in a combination formula with other estrogen supporting nutrients. This article provides a comprehensive overview of DIM supplements, including their benefits and side effects. Can I try diming out for myself? Is it ok to drink alcohol while taking DIM capsules? The other metabolites, 4OHE1 and 16OHE1 are associated with unfavorable growths of breast and uterine tissue, including cancer. People on hormone therapies or with certain hormone-related cancers should avoid these supplements. Other ovulation pain symptoms include light vaginal bleeding and discharge. PMS symptoms are worsening. Research also shows promising anti-tumor activity of DIM.1 Diindolylmethane (DIM . DIM supplements may safeguard against prostate enlargement and prostate cancer. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis. I'm just wondering if it works for some and not others. I see that you are supposed to take other supplements at certain times in your cycle, when should I take DIM? This is harmless and will go away once you stop taking DIM. While the exact mechanism is unknown, indole-3-carbinol is thought to be partly responsible (4, 5, 6). It also functions as an anabolic hormone. Dim lights can also trigger migraine headaches for people who suffer from them. Certain medical issues might also have an impact on your menstruation. I wasn't sure if it was the Progesterone or if it was just a fluke. Exercise decreases "bad" estrogen levels and helps your body make more of the "good" estrogens. I know it removes excess estrogen but is there any chance it may remove too much? Taking regular breaks from vitex can prevent attenuation of its effects. I had stopped taking it and done more research into DIM. This can result in painful cramps, heavy periods, pain with sex, and spotting between periods. If you dont like them by themselves, include them in smoothies or baked dishes. of natural progesterone (another brand) and cleaning out a majority of the possible hormone disrupters in my life mid November 2014. DIM works at the Phase 1 detox level to help your liver make the most favorable metabolite, 2OHE1 and reduce the excess production of potentially harmful 4OHE1 and 16OHE1. there is not enough progesterone to oppose estrogen). Youll also benefit from the other vitamins, minerals, and fiber they provide. It is important to lose weight if you want to manage these conditions or others related to obesity. Hi Shifa! Calcium D-glucarate inhibits beta-glucuronidase, see. It removes carcinogens, toxins, tumour promoters, the sex hormones ie, the androgens and oestrogens, mineralocorticoids and glucocorticoids, aromatic and heterocyclic amines, polycyclic aromatic hydrocarbons, various nitrosamines, drugs, fungi etc. The average duration is three to four years, although it can last just a few months or extend as long as a decade. Estrogen increases fluid retention, but progesterone decreases that additional fluid by acting as a diuretic. All About Natural and Pharmaceutical Estrogen Blockers for Males, Our Favorite Healthy Finds: Organic Beauty Products for Acne-Prone Skin, The 12 Best Collagen Supplements for Better Skin. I began using about 60mg. I don't need to be shelling out the extra bucks anywaylol. Studies on DIM have shown promise for breast health, acne, and reducing PMS. When the endometrial lining is overstimulated it can result in endometrial hyperplasia, which can lead to heavier periods. Periods that are irregular. Side Effects of DIM. DIM can also potentially affect your period. Use 6 days and take a 1-day break every 7 days (so 4 days of "rest" each month). Physical activity: Getting regular physical activity has been proven to relieve PMS symptoms like bloating. While a DIM supplement may be helpful for some women, it is not essential for everyone. This transitional period before menopause is known as perimenopause, and it can begin long before you enter menopause. DIM is supposed to help regulate estrogen levels in the body, while research on it is relatively restricted ( 1 ). Maintain a healthy body weight. If you do decide to take Vitex, don't take it for longer than 3-6 months maximum at a time, then stop and see how your hormones are without it. In Phase 2 detox these metabolites are methylated and prepared for excretion via the kidneys and bowels. I know the dosage is low compared to what is advised on this site. Exercise on a regular basis. Because it helps move estrogen down the pathway that produces more favorable estrogen metabolites, DIM may be useful for women struggling with estrogen dominance, PMS, period problems, perimenopause, and menopause. The recommended dosage of myo-inositol for most women with PCOS is 4000 mg/day taken in two doses. See what's being discussed, ask for help, give your thoughts or experiences, or just browse Its free and will bring you important new information on progesterone therapy and related health matters, Home|Contact|Newsletter|Index of Symptoms|News|Progesterone cream|Privacy policy|Blog|About|FAQ. Finally, being obese increases your risk of developing diseases such as heart disease, stroke, type 2 diabetes, and cancer. All rights reserved. DIM may also have an impact on your menstrual cycle. The best estrogen metabolite is 2-hydroxy estrone (2OHE1), which DIM promotes over the problematic estrogen metabolite, 16 alpha-hydroxy estrone (16OHE1). Perimenopause is the period between a womans later reproductive years and menopause. Due to limited research, proper dosages for DIM are unknown. So, which one is it: is estrogen supposed to be high or low during perimenopause? DIM benefits include supporting a healthy menopausal transition, promoting hormonal balance in those with polycystic ovarian syndrome (PCOS). Fortunately, there are steps that you can take to reduce period bloating, which include: 3. Less common side effects included nausea, diarrhea, vomiting and a skin rash. "The daily recommended intake of 600 IUs is debatable since studies show higher amounts of D are necessary for disease- and cancer-prevention benefits." Start by getting your levels checked to. Concentration issues Irritability and moodiness. However, a study in 24 healthy people found that although DIM doses of up to 200 mg were well tolerated and didnt cause side effects, one person experienced nausea, headache, and vomiting after taking a 300-mg dose, suggesting that higher doses may be associated with adverse side effects (15). No matter DIMs effectiveness, its always good to eat more cruciferous veggies. I began taking around 80 mg a day. Estrogen imbalances have been linked to weight gain in both men and women, especially during menopause and andropause, when estrogen levels are most variable. I recently ran out of the DIM and noticed my night sweats went away on day 2 of not taking them. "It binds to the androgen receptor so that there's no 'hole' for the androgen 'keys' to bind to," says Dr . Supplements work gently and gradually, so they must be taken every day throughout the month not just during your period. Your menstrual cycle might be regular about the same length every month or somewhat irregular, and your period . Choosing a dose. Secondly, Should DIM be taken with or without food? However, human studies are limited (1, 2). Featuring a 28 day plan to take back your cycle and dozens of charts, checklists, and diagrams to help along the way. People who take dim out of concern for its potential negative effects are likely overthinking things. Poor nutrition and lack of exercise can also cause ovarian dysfunction. The third, Hello, i 25 years old and am taking 400 mg of Progesterone since 8 months and a lot of my many symptoms improved but I also didn't have a period since. The best answer I can give you is when your cycle begins, so if you dont know when your cycle has begun, then its best to ask your doctor. Limited studies suggest that DIM supplements may help reduce prostate enlargement and protect against certain cancers. However, DIM supplements are available over-the-counter and online. Women with PCOS often have hormonal imbalances that cause hirsutism (unwanted hair growth on the face and body) and acne. So if you take DIM during your period time and start BO with Vitex it helps a lot. Testosterone is an androgen that controls and governs masculine features such as male genital development, a deeper voice, and the distribution of body hair. Before using DIM, those who are at a greater risk for estrogen-sensitive malignancies other hormone-related diseases should talk to their doctor. Its important to note that a higher dose of DIM was used because this was a study on patients with thyroid proliferative disease. Then put a lot of lubricant on your fingertips. The good news is that you dont always need to rely on painkillers or the pill as the only treatment for these conditions. Studies have shown that women in perimenopause and menopause experience a reduced health-related quality of life, as well as higher work impairment. Where do you start if DIM stopped working for you? In addition, DIM may help repair damaged DNA. The DIM compound may have several estrogen-related effects in your body:. It takes a lot of DIM to mess with your sodium on its own, but if youre taking diuretics, you might reach your limit faster. For some people, periods stop altogether. Thanks so much Diane, for your support and input in helping me figure this out. Due to insufficient evidence, dosage information for DIM is lacking. Problems can arise when there is too much estrogen circulating in our bodies or the wrong metabolites. They are responsible for producing estrogen and regulating the menstrual cycle. "I would say about 10% of my clients who have used DIM see a change in their menstrual . Put the lubricant around the tampon and try to slide it out. Before trying any supplement, talk to your doctor. It's great that it works for you and your daughter. I've been taking Lugol's 2% but it makes my stomach upset to take it by mouth, so I rub it on my skin. Always talk to your doctor before adding a supplement to your diet., Denver Vein Center: DIM Supplements: What You Need to Know., Harvard Health: By the way, doctor: What does Indolplex do? Getting your vitamins and minerals through diet., Memorial Sloan Kettering Cancer Center: Diindolylmethane., Toxicology Letters: Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR.. When broccoli, cauliflower, and other cruciferous vegetables are exposed to stomach acid after chewing, indole-3-carbinol is created, which is then converted into DIM. Supplements may be boosted for better absorption. Due to a lack of research in humans, little is known about the long-term safety and side effects of DIM supplements. How? Theyre also used to help prevent prostate enlargement, treat acne, aid weight loss, and reduce premenstrual syndrome (PMS) and menopause symptoms. A fierce patient advocate and completely dedicated to uncovering the root cause of hormonal imbalances, Dr. Brighten empowers women worldwide to take control of their health and their hormones. Dim lighting has been known to help regulate the release of hormones that cause your period to arrive. But, like all hormones, it needs to be balanced. If you prefer a plant-based, whole food supplement option, here's a great estrogen detox product backed by good science. I've had a Thyroidectomy 7 years ago. For instance, some studies suggest DIM encourages the death of cancer cells. The Benefits of DIM. What Happens to Your Body During the TWW? No matter your medical history, its important to consult your healthcare provider before taking these supplements. I don't feel like the lugol's is doing much for me.